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Title: Evaluation of a Diet Rich in Monounsaturated Fatty Acids (MUFAs) on Reduction of Visceral Fat in the Abdomen: A Pilot Study
Status: Completed
Topic: Nutrition / Diet
Funding Source: Prevention Magazine
Funding Period: 2008
Study Design: Pilot Study with One Treatment Assignment
Purpose: To assess the effects of a 4-week diet rich in monounsaturated fatty acids (MUFAs) on the reduction of visceral fat, as measured by MRI of the abdomen. This type of fat has been linked to higher risk of atherosclerosis (plaque build up in the arteries that can lead to heart attack and stroke) and insulin resistance (a precursor to diabetes). The benefits of a diet rich in MUFA have been demonstrated by previous research. The purpose of this study was to examine the potential benefits of an eating plan with high level of MUFAs that is easy for people to understand and adopt.
Further Study Details: A total of 10 women were enrolled in the dietary intervention; there was no control diet for this pilot study. Participants were evaluated at baseline and at the completion of the 4-week dietary intervention. The primary outcome measure was a change in visceral fat mass as measured by magnetic resonance imaging (MRI).
Findings: Following the diet for 4 weeks led to statistically significant reductions in visceral fat, weight, waist circumference, total cholesterol, triglycerides, fasting insulin, and HOMA-IR (a measure of insulin resistance). A slight decrease in HDL (the “good” cholesterol) was shown and there were also trends toward reductions in LDL cholesterol, blood pressure, blood glucose, and C-reactive protein, but these were not statistically significant.
Eligibility: Women aged 35-75 years with BMI≥30 and waist circumference of at least 34 inches.

Changed at: 1/18/2011 9:42 AM Changed by: Judy Treu
Created at: 8/31/2010 11:19 AM Created by: Griffin Hospital