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Title: Acute Nutrient Effects on Endothelial Function: A Randomized, Single-Blind Crossover Trial in Healthy Adults
Status: Completed
Topic: Cardiovascular Health / Endothelial Function*
Funding Source: The Quaker Oats Company
Funding Period: 7/98-6/99
Study Design: Randomized, Single-Blind Crossover Trial
Purpose: To determine the effects of acute and month-long whole grain oat and wheat cereal ingestion on endothelial function in healthy adults following a high-fat meal.
Further Study Details: A total of 50 adults (25 men and 25 women) participated in this study. Participants underwent endothelial function (BARS) testing at the beginning of the study, and after following each of the 3 different treatment assignments - whole grain oatmeal plus high-fat milkshake, wheat cereal plus high-fat milkshake, and vitamin E plus high-fat milkshake. Participants were then assigned, in random order, to 4-week intake of oat and wheat cereals. Endothelial function (BARS) testing was done at the completion of each 4-week treatment assignment.
Findings: The findings confirmed that acute fat ingestion induced endothelial dysfunction in healthy adults. Both vitamin E and oatmeal in the doses tested preserved normal endothelial function when ingested concurrently with a high-fat meal. In the month-long supplementation, oats and wheat had comparable effects on endothelial function. These results suggested that nutrient distribution and meal composition may have had significant implications for cardiovascular health.
Eligibility: Healthy men (35-75 years of age) and women (postmenopausal-75 years of age).

Changed at: 1/18/2011 5:15 AM Changed by: Judy Treu
Created at: 8/31/2010 9:33 AM Created by: Griffin Hospital