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Title: Oats, Antioxidants, and Endothelial Function in Insulin Resistant Adults
Status: Completed
Topic: Cardiovascular Health / Endothelial Function*
Funding Source: The Quaker Oats Company
Funding Period: 10/99-7/01
Study Design: Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Purpose: The purpose of this study was to determine the effects of oats and antioxidant vitamins on endothelial function in adults with features of insulin resistance. While metabolic benefits of soluble fiber-rich grains in insulin resistance (which can lead to diabetes) are well known, effects on endothelial function (a marker of heart health) have not been reported. Eligibility: Adult men (35-75 years of age) and women (postmenopausal-75 years of age) with features of insulin resistance (overweight, hypertriglyceridemia).
Further Study Details: The 30 participants in this study were assigned, in random order, to 4 different treatments: oats plus vitamin E and C, oats plus placebo vitamin E & C, vitamin E & C only, and placebo vitamin E & C. Treatment assignments were taken daily for a period of 6 weeks. Endothelial function (BARS) testing was done at the beginning of the study (after a onetime intake of each treatment), and again following each 6-week assignment.
Findings: Results indicated that oats improved endothelial dysfunction in adults with features of insulin resistance, with particularly strong effects in women. Immediate beneficial effects were found on endothelial function from eating a single bowl of oatmeal, with greater benefit seen from eating oats daily for 6 weeks. These findings were consistent with previous study of oat ingestion in healthy adults (see below). The antioxidant vitamins, E and C, did not provide any benefit, and actually seemed to have a negative effect in the women in this study.
Eligibility: Adult men (35-75 years of age) and women (postmenopausal-75 years of age) with features of insulin resistance (overweight, hypertriglyceridemia).

Changed at: 1/18/2011 5:14 AM Changed by: Judy Treu
Created at: 8/31/2010 9:31 AM Created by: Griffin Hospital