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Title: Effects of Fruit and Nut KIND Bars on Endothelial Function in Overweight Adults
Status: Completed
Topic: Cardiovascular Health / Endothelial Function*
Funding Source: Peace Works Holdings, LLC
Funding Period: 2008-2009
Study Design: Pilot Study
Purpose: To determine the effects of a diet enriched with KIND Fruit and Nut snack bars twice daily for an 8 week period on endothelial function/heart health and related risks in overweight adults with one additional risk factor for insulin resistance.
Further Study Details: During Phase 1 of this study, 19 men and women consumed two KIND Fruit and Nut snack bars daily for 8 weeks. Participants underwent endothelial testing (BARS – see description above) and laboratory testing before and after the treatment period to determine the effect that KIND Fruit and Nut bars have on heart health and related markers (i.e., blood pressure, cholesterol, etc). Phase 2 follows a larger sample size of 100 more participants (50 in the intervention group and 50 in the control group) to examine the effects of eating 2 KIND bars per day for 8 weeks on weight and blood pressure.
Findings: The results of the pilot study (Phase 1) did not reflect a statistically significant change in endothelial function (the primary outcome of interest). However, we did observe downward trends in weight and blood pressure after 8 weeks of KIND bar consumption. Since the sample size of 19 adults may have been too small to show statistical significance, a follow-up study is underway to with 100 additional participants.
Eligibility: Adults with a body-mass index greater than 25.0, and one or more additional risk factors for insulin resistance: abdominal obesity determined by waist circumference >102 cm (>40 in) in men or >88 cm (>35 in) in women; elevated triglyceride level; HDL-C <40 mg/dL in men or <50 mg/dL in women; elevated blood pressure; and/or fasting glucose ≥100 mg/dL.

Changed at: 1/17/2011 10:57 AM Changed by: Judy Treu
Created at: 8/30/2010 11:45 AM Created by: Griffin Hospital