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Title: Effects of Walnut Consumption on Endothelial Function in Type 2 Diabetes: A Randomized, Controlled, Cross–Over Trial
Status: Completed
Topic: Cardiovascular Health / Endothelial Function*
Funding Source: California Walnut Commission
Funding Period: 2007-2009
Study Design: Randomized, Controlled, Cross–Over Trial
Purpose: To determine if consumption of walnuts improves endothelial function and lipid markers in people with Type 2 diabetes.
Further Study Details:

Study participants were required to maintain their normal/routine (ad libitum) diet while participating in this study. Their dietary patterns were assessed upon enrollment in the study to establish baseline values. The study consisted of two phases and participants were randomly assigned to each of the two treatment assignments:

  1. supplementation of the diet with 1.5 ounces or 42 grams of walnuts, or
  2. a diet without walnut supplementation for 8 weeks. Participants were then switched to the other treatment assignment for the second 8 week period.
Findings: When people with Type 2 diabetes followed the walnut-enriched diet on a daily basis for 8 weeks, they had a statistically significant improvement in endothelial function compared to when they followed their usual diets. They also had a trend toward lower levels of total and LDL cholesterol, but this was not statistically significant. No significant changes were found in body mass index, weight, waist circumference, triglycerides, HDL cholesterol, or fasting plasma glucose.
Eligibility: Adults between the ages of 35 and 65 who had been diagnosed with type 2 diabetes

Changed at: 1/17/2011 10:55 AM Changed by: Judy Treu
Created at: 8/30/2010 10:25 AM Created by: Griffin Hospital